Title of article
Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes Original Research Article
Author/Authors
Lanrong Bi، نويسنده , , Yue Zhang، نويسنده , , Ming Zhao، نويسنده , , Chao Wang، نويسنده , , Priscilla Chan، نويسنده , , Jeffrey B. -H. Tok، نويسنده , , Shiqi Peng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
7
From page
5640
To page
5646
Abstract
A novel stereospecific synthetic route to obtain a series of 2,5-disubstituted-dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene-induced ear edema in mice, the structure–activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified.
Keywords
Acetalization , Anti-inflammatory activity , 2 , 5-Disubstituted-dioxacycloalkanes
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304912
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