Title of article
Branched aminoglycosides: Biochemical studies and antibacterial activity of neomycin B derivatives Original Research Article
Author/Authors
Mariana Hainrichson، نويسنده , , Varvara Pokrovskaya، نويسنده , , Dalia Shallom-Shezifi، نويسنده , , Micha Fridman، نويسنده , , Valery Belakhov، نويسنده , , Dina Shachar، نويسنده , , Sima Yaron، نويسنده , , Timor Baasov، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
11
From page
5797
To page
5807
Abstract
The C5″-OH group in neomycin B was glycosylated with a variety of mono- and di-saccharides to probe the effect of introduction of additional binding elements on antibacterial activity and interaction with the aminoglycosides modifying enzyme APH(3′)-IIIa. The designed structures show antibacterial activity superior to that of neomycin B against pathogenic and resistant strains, while in parallel they demonstrate poor substrate activity with APH(3′)-IIIa.
Keywords
aminoglycosides , Antibiotics , antibiotic resistance , Pseudomonas aeruginosa
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304929
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