Title of article
Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists Original Research Article
Author/Authors
Jeffrey C. Pelletier، نويسنده , , John Rogers، نويسنده , , Jay Wrobel، نويسنده , , M. Claudia Perez، نويسنده , , Emily S. Shen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
10
From page
5986
To page
5995
Abstract
An unusual combination of Weinreb amidation and Mitsunobu lactam formation was used to prepare highly substituted γ-lactam analogues of a thiazolidinone follicle stimulating hormone receptor agonist. The analogue synthesis was stereoselective and the final products were chemically stable. Biological properties of the target molecules were nearly identical to those of the lead compound.
Keywords
FSH , Follicle stimulating hormone , Mitsunobu reaction
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304949
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