Title of article
Biological activities of retinoidal γ-hydroxybutenolides in cancer cell apoptosis and differentiation Original Research Article
Author/Authors
Yumiko Yamano، نويسنده , , Yukari Mizuguchi، نويسنده , , Yumi Fujita، نويسنده , , Maki Yoshida، نويسنده , , Masayoshi Ito، نويسنده , , Kimie Nakagawa، نويسنده , , Toshio Okano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
7
From page
6002
To page
6008
Abstract
Retinoidal γ-hydroxybutenolides 2a–d having various lengths of conjugated double bond were prepared in three steps from the corresponding aldehyde 4. Their biological activities were then measured. Of these compounds, only compound 2c possessing a structure similar to that of retinoic acid showed differentiation-inducing activity and very strong apoptosis-inducing activity in HL-60 cells.
Keywords
Differentiation-inducing activity , Apoptosis-inducing activity , Retinoic acid , ?-Hydroxybutenolides
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304951
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