Title of article :
Cytotoxic diterpenoids from two lianas from the Suriname rainforest Original Research Article
Author/Authors :
Eba Adou، نويسنده , , Russell B. Williams، نويسنده , , Jennifer K. Schilling، نويسنده , , Stan Malone، نويسنده , , Jan Meyer، نويسنده , , Jan H. Wisse، نويسنده , , Djon Frederik، نويسنده , , Delon Koese، نويسنده , , Marga C.M. Werkhoven، نويسنده , , Carl E. Snipes، نويسنده , , Todd L. Werk، نويسنده , , David G.I Kingston، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids, humirianthone 1, 1-hydroxy-humirianthone 2, 15R-humirianthol 3, patagonol 4, and patagonal 5, and the five known diterpenoids, humirianthol 7, annonalide 8, acrenol 9, icacinol 10, and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line, and compounds 1, 3, 8, and 9 also showed activity against phytopathogenic fungi.
Keywords :
Icacinaceae , Cytotoxicity , Annonalide , Diterpenoids , Humirianthol , Phytopathogen
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
