Title of article :
‘O-Acyl isopeptide method’ for the efficient preparation of amyloid β peptide 1–42 mutants Original Research Article
Author/Authors :
Youhei Sohma، نويسنده , , Yousuke Chiyomori، نويسنده , , Maiko Kimura، نويسنده , , Fukue Fukao، نويسنده , , Atsuhiko Taniguchi، نويسنده , , Yoshio Hayashi، نويسنده , , Tooru Kimura، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Novel water-soluble isopeptides of Aβ1–42 mutants, ‘26-O-acyl isoAβ1–42 (26-AIAβ42) mutants’, which were efficiently converted to intact Aβ1–42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Aβ1–42 mutants.
Keywords :
Alzheimer’s disease , O-Acyl isopeptide method , A?1–42 , A?1–42 mutant , O–N intramolecular acyl migration reaction , 26-AIA?42
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
