Title of article
Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile Original Research Article
Author/Authors
George N. Ziakas، نويسنده , , Eleni A. Rekka، نويسنده , , Antonios M. Gavalas، نويسنده , , Phaedra T. Eleftheriou، نويسنده , , Karyofillis C. Tsiakitzis، نويسنده , , Panos N. Kourounakis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
6485
To page
6492
Abstract
Tolfenamic acid esters with nitrooxyalcohols are synthesized. They are anti-inflammatory agents reducing carrageenan rat paw edema, with low gastrointestinal and general toxicity. In vitro, they are nitric oxide donors, inhibitors of lipoxygenase and cyclooxygenases. A two to three carbon chain between carboxylic and nitric ester groups seems optimal for activity.
Keywords
anti-inflammatory agents , Tolfenamic acid esters , Nitric oxide donors , cyclooxygenase inhibition , Lipoxygenase
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305001
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