Title of article
Water-soluble chitosan derivatives as a BACE1 inhibitor Original Research Article
Author/Authors
Jae-Young Je، نويسنده , , Se-Kwon Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
6551
To page
6555
Abstract
BACE1 (the β-site APP-cleaving enzyme) inhibitory activities of water-soluble chitosan derivatives substituted with aminoethyl, dimethylaminoethyl and diethylaminoethyl groups were investigated. AE-chitosan (90%) prepared from 90% deacetylated chitosan showed the strongest BACE1 inhibitory activity than those of other derivatives. The inhibitory pattern was found to be non-competitive by Dixon plot, and the value of the inhibition constant (Ki) was 85 μg/mL.
Keywords
Water-soluble chitosan , BACE1 , Non-competitive , AE-chitosan
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305006
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