Title of article
Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa Original Research Article
Author/Authors
Anna Aiello، نويسنده , , Monica D’Esposito، نويسنده , , Ernesto Fattorusso، نويسنده , , Marialuisa Menna، نويسنده , , Werner E.G. Muller، نويسنده , , Sanja Perovi?-Ottstadt، نويسنده , , Heinz C. SchrOder ، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
17
To page
24
Abstract
The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5–18, four novel alkaloids of this class, compounds 1–4, have been isolated, and their structures established through spectroscopic methods. Compounds 1–4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.
Keywords
Marine sponges , Natural products , Bromopyrrole alkaloids , Axinella verrucosa , neuroprotective activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305040
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