Author/Authors :
Francesco Peri، نويسنده , , Chiara Marinzi، نويسنده , , Marek Barath، نويسنده , , Francesca Granucci، نويسنده , , Matteo Urbano، نويسنده , , Francesco Nicotra، نويسنده ,
Abstract :
A mimetic of Lipid A with a β-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its β-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity.
