Title of article
Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Original Research Article
Author/Authors
Sandra Sinishtaj، نويسنده , , Heung Bae Jeon، نويسنده , , Patrick Dolan، نويسنده , , Thomas W. Kensler، نويسنده , , Gary H. Posner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
6341
To page
6348
Abstract
Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2–4 are as antiproliferative in vitro as calcitriol (1) but are 20–40 times less calciuric in vivo than calcitriol (1).
Keywords
Vitamin D , Calcitriol , Antiproliferative
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305091
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