Author/Authors :
Shingo Yamamoto، نويسنده , , Shingo Nakatani، نويسنده , , Masahiro Ikura، نويسنده , , Tsuneyuki Sugiura، نويسنده , , Yoshitaka Nishita، نويسنده , , Satoshi Itadani، نويسنده , , Koji Ogawa، نويسنده , , Hiroyuki Ohno، نويسنده , , Kanji Takahashi، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in exhibited strong inhibitory activity against MMP-2 and MMP-9, as well as even stronger inhibitory activity against MMP-3, but showed relatively weak inhibition of MMP-1. Structure–activity relationships are discussed.
Keywords :
MMP , Matrix metalloproteinase inhibitor , Hydroxamate inhibitor , l-Glutamic acid
