Title of article
Design and synthesis of an orally active matrix metalloproteinase inhibitor Original Research Article
Author/Authors
Shingo Yamamoto، نويسنده , , Shingo Nakatani، نويسنده , , Masahiro Ikura، نويسنده , , Tsuneyuki Sugiura، نويسنده , , Yoshitaka Nishita، نويسنده , , Satoshi Itadani، نويسنده , , Koji Ogawa، نويسنده , , Hiroyuki Ohno، نويسنده , , Kanji Takahashi، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
21
From page
6383
To page
6403
Abstract
A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in exhibited strong inhibitory activity against MMP-2 and MMP-9, as well as even stronger inhibitory activity against MMP-3, but showed relatively weak inhibition of MMP-1. Structure–activity relationships are discussed.
Keywords
MMP , Matrix metalloproteinase inhibitor , Hydroxamate inhibitor , l-Glutamic acid
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305095
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