Title of article :
Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416 Original Research Article
Author/Authors :
Bulbul Pandit، نويسنده , , Yanjun Sun، نويسنده , , Ping Chen، نويسنده , , Dan L. Sackett، نويسنده , , Zhigen Hu، نويسنده , , Wendy Rich، نويسنده , , Chenglong Li، نويسنده , , James Andrew Lewis، نويسنده , , Kevin Schaefer، نويسنده , , Pui-Kai Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.
Keywords :
Antitumor agents , Antimicrotubule , SU5416 , Colchicine , Cell cycle arrest , Combretastatins
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
