Title of article
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents Original Research Article
Author/Authors
Tsuyoshi Shinozuka، نويسنده , , Kousei Shimada، نويسنده , , Satoshi Matsui، نويسنده , , Takahiro Yamane، نويسنده , , Mayumi Ama، نويسنده , , Takeshi Fukuda، نويسنده , , Motohiko Taki، نويسنده , , Yuko Takeda، نويسنده , , Eri Otsuka، نويسنده , , Michiko Yamato، نويسنده , , Satoru Naito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
13
From page
6807
To page
6819
Abstract
A modification of novel cathepsin K inhibitors I was carried out. The structural design was aimed at reducing the lipophilic character of compounds I for obtaining better pharmacokinetic profiles. This modification afforded several less lipophilic compounds with good inhibitory activities and pharmacokinetic profiles, although the enzyme selectivity over cathepsin S was left at issue.
Keywords
cathepsin K , Inhibitor , Heterocyclic substituent , SAR study
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305172
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