Author/Authors :
Tsuyoshi Shinozuka، نويسنده , , Kousei Shimada، نويسنده , , Satoshi Matsui، نويسنده , , Takahiro Yamane، نويسنده , , Mayumi Ama، نويسنده , , Takeshi Fukuda، نويسنده , , Motohiko Taki، نويسنده , , Yuko Takeda، نويسنده , , Eri Otsuka، نويسنده , , Michiko Yamato، نويسنده , , Satoru Naito، نويسنده ,
Abstract :
A modification of novel cathepsin K inhibitors I was carried out. The structural design was aimed at reducing the lipophilic character of compounds I for obtaining better pharmacokinetic profiles. This modification afforded several less lipophilic compounds with good inhibitory activities and pharmacokinetic profiles, although the enzyme selectivity over cathepsin S was left at issue.
Keywords :
cathepsin K , Inhibitor , Heterocyclic substituent , SAR study
