Title of article :
Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents Original Research Article
Author/Authors :
Jean Guillon، نويسنده , , Isabelle Forfar-Bares، نويسنده , , Maria Mamani-Matsuda، نويسنده , , Vanessa Desplat، نويسنده , , Marion Saliège، نويسنده , , Denis Thiolat، نويسنده , , Stéphane Massip، نويسنده , , Anais Tabourier، نويسنده , , Jean-Michel Leger، نويسنده , , Benoit Dufaure، نويسنده , , Gilbert Haumont، نويسنده , , Christian Jarry، نويسنده , , Djavad Mossalayi، نويسنده ,
Abstract :
An original series of 4-substituted pyrrolo[1,2-a]quinoxaline derivatives, new structural analogues of Galipea species quinoline alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure–activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the pyrrolo[1,2-a]quinoxaline moiety to modulate the antileishmanial activity.
Keywords :
2-a]quinoxaline derivatives , Synthesis , Antileishmanial activity , Lipohilicity
