Title of article
Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems Original Research Article
Author/Authors
Takahisa Maruyama، نويسنده , , Yuko Kano، نويسنده , , Yasuo Yamamoto، نويسنده , , Mizuyo Kurazono، نويسنده , , Katsuyoshi Iwamatsu، نويسنده , , Kunio Atsumi، نويسنده , , Eiki Shitara، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
11
From page
392
To page
402
Abstract
A new series of 1β-methyl carbapenems, possessing a 7-substituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus, was synthesized and evaluated for antibacterial activity. These compounds showed potent activities against Gram-positive bacteria, in particular methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae (PRSP). They also exhibited potent activity against β-lactamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR).
Keywords
Carbapenem , 1-b]thiazole , 1-b]thiazol-2-yl group , anti-MRSA activity , MRSA , PRSP , BLNAR
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305285
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