Title of article
Chiral multinuclear macrocyclic polyamine complexes: Synthesis, characterization and their interaction with plasmid DNA Original Research Article
Author/Authors
Yu-Guo Fang، نويسنده , , Ji Zhang، نويسنده , , Shan-Yong Chen، نويسنده , , Ning Jiang، نويسنده , , Hong-Hui Lin، نويسنده , , Yu Zhang، نويسنده , , Xiao-Qi Yu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
696
To page
701
Abstract
A series of multinuclear macrocyclic polyamine metal (Zn2+, Cu2+, Co2+) complexes containing chiral dipeptide linkage were synthesized and used as artificial nuclease enzyme model. The interaction between the complexes and plasmid DNA (pUC19) was studied, and the results revealed that these complexes could act as powerful catalysts for the cleavage of plasmid DNA under physiological conditions.
Keywords
Chemical nuclease , 1 , 4 , 7 , Macrocyclic polyamine , Multinuclear complexes , 10-Tetraazacyclododecane (cyclen) , DNA cleavage
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305314
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