Author/Authors :
Simona Collina، نويسنده , , Guya Loddo، نويسنده , , Mariangela Urbano، نويسنده , , Laura Linati، نويسنده , , Athos Callegari، نويسنده , , Francesco Ortuso، نويسنده , , Stefano Alcaro، نويسنده , , Christian Laggner، نويسنده , , Thierry Langer، نويسنده , , Orazio Prezzavento، نويسنده , , Giuseppe Ronsisvalle، نويسنده , , Ornella Azzolina، نويسنده ,
Abstract :
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to σ1 and σ2 receptors. Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σ2. A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.
Keywords :
Molecular modeling , SAR studies , Arylalkylamines , Sigma receptors
