Title of article :
Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke Original Research Article
Author/Authors :
Harunobu Mukaiyama، نويسنده , , Toshihiro Nishimura، نويسنده , , Satoko Kobayashi، نويسنده , , Tomonaga Ozawa، نويسنده , , Noboru Kamada، نويسنده , , Yoshimitsu Komatsu، نويسنده , , Shinji Kikuchi، نويسنده , , Hideki Oonota، نويسنده , , Hiroshi Kusama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
We synthesized and evaluated a series of C-5 substituted imidazo[1,5-a]pyrazine derivatives to identify potent c-Src inhibitors as potential therapeutic agents for acute ischemic stroke. Among these compounds, compound 14c·HCl demonstrated remarkable central nervous system (CNS) penetration and significant neuroprotective efficacy in vivo in rat models.
Keywords :
CH–? interaction , c-Src , Brain ischemia , 5-a]pyrazine , Central nervous system (CNS) penetration
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
