Title of article
Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists Original Research Article
Author/Authors
Jun Chiba، نويسنده , , Shin Iimura، نويسنده , , Yoshiyuki Yoneda، نويسنده , , Toshiyuki Watanabe، نويسنده , , Fumito Muro، نويسنده , , Masao Tsubokawa، نويسنده , , Yutaka Iigou، نويسنده , , Atsushi Satoh، نويسنده , , Gensuke Takayama، نويسنده , , Mika Yokoyama، نويسنده , , Tohru Takashi، نويسنده , , Atsushi Nakayama، نويسنده , , Nobuo Machinaga، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
15
From page
1679
To page
1693
Abstract
A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic properties. In particular, 12l demonstrated an a
Keywords
Integrin , VLA-4 , Oral availability
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305377
Link To Document