Title of article
Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative Original Research Article
Author/Authors
Yoshihide Hattori، نويسنده , , Hitoshi Yamamoto، نويسنده , , Hideya Ando، نويسنده , , Hirofumi Kondoh، نويسنده , , Tomoyuki Asano، نويسنده , , Mitsunori Kirihata، نويسنده , , Yoshihiro Yamaguchi، نويسنده , , Tateaki Wakamiya، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
2198
To page
2205
Abstract
Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical tools for BNCT and MRI, novel compounds containing both the trifluoromethyl group and 10B atom in a single molecule were designed. In the present study, p-boronophenylalanine and p-boronophenylalaninol with the trifluoromethyl group were synthesized, and 19F NMR measurements of these compounds were carried out.
Keywords
6-trifluoromethylphenyl]alaninol , 6-trifluoromethylphenyl]alanine , Boron-neutron capture therapy , Magnetic resonance imaging , ?-1
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305425
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