Title of article
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration Original Research Article
Author/Authors
Takashi Kondo، نويسنده , , Takahiro Nekado، نويسنده , , Isamu Sugimoto، نويسنده , , Kenya Ochi، نويسنده , , Shigeyuki Takai، نويسنده , , Atsushi Kinoshita، نويسنده , , Yohei Tajima، نويسنده , , SUSUMU YAMAMOTO، نويسنده , , Kazuhito Kawabata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
20
From page
2631
To page
2650
Abstract
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure–activity relationships are also presented.
Keywords
DPP-IV inhibitor , Prolyl-2-cyanopyrrolidine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305456
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