Title of article
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV Original Research Article
Author/Authors
Takashi Kondo، نويسنده , , Isamu Sugimoto، نويسنده , , Takahiro Nekado، نويسنده , , Kenya Ochi، نويسنده , , Tazumi Ohtani، نويسنده , , Yohei Tajima، نويسنده , , SUSUMU YAMAMOTO، نويسنده , , Kazuhito Kawabata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
21
From page
2715
To page
2735
Abstract
A series of (4-substituted prolyl)prolinenitriles were synthesized and evaluated as inhibitors of dipeptidylpeptidase IV (DPP-IV). Among those tested, the 4β-[4-(hydroxyphenyl)prolyl]prolinenitriles showed a potent inhibitory activity with a long duration of action. Metabolic formation of the corresponding phenol glucuronates was found to contribute to their long duration of action. The activity profiles of the synthesized compounds are reported and structure–activity relationships are also presented.
Keywords
DPP-IV inhibitor , Prolylprolinenitriles , Glucuronate
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305464
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