Synthesis and biological evaluation of phosphonated carbocyclic 2′-oxa-3′-aza-nucleosides Original Research Article

The synthesis of carbocyclic 2′-oxa-3′-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.