A QSAR study on influenza neuraminidase inhibitors Original Research Article

Influenza is a major respiratory infection associated with significant morbidity in the general population and mortality in elderly and high-risk patients. It is an RNA virus that contains two major surface glycoproteins, neuraminidase and hemagglutinin. These proteins are essential for infection. Neuraminidase has been found to be a potential target to control influenza virus. In this paper, we have developed 17 quantitative structure–activity relationships (QSAR) for different sets of compounds to understand chemical–biological interactions governing their activities toward influenza neuraminidase.