Title of article
Synthesis and biological evaluation of N-(7-indazolyl)benzenesulfonamide derivatives as potent cell cycle inhibitors Original Research Article
Author/Authors
L. Bouissane، نويسنده , , S. El Kazzouli، نويسنده , , S. Léonce، نويسنده , , B. Pfeiffer، نويسنده , , E.M. Rakib، نويسنده , , M. Khouili، نويسنده , , G. Guillaumet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
11
From page
1078
To page
1088
Abstract
We herein describe a new synthesis of N-(7-indazolyl)benzenesulfonamide derivatives. These compounds were evaluated for their antiproliferative activities toward L1210 murine leukemia cells. One of them, 4-methoxy-N-(3-chloro-7-indazolyl)benzenesulfonamide, was identified as the most potent with an IC50 of 0.44 μM.
Keywords
Sulfonamide , L1210 murine leukemia cells , Indazole , Palladium
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305488
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