Title of article :
Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents Original Research Article
Author/Authors :
Shagufta، نويسنده , , Ajay Kumar Srivastava، نويسنده , , Ramesh Sharma، نويسنده , , Rajeev Mishra، نويسنده , , Anil Kumar Balapure، نويسنده , , Puvvada S.R. Murthy، نويسنده , , Gautam Panda، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC50 in the range of 3.53–22.25 μM. One of the compounds 15ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
Keywords :
Substituted phenanthrenes , Basic amino side chain , Anti-breast cancer agents
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
