Author/Authors :
Hong Bin Zou، نويسنده , , Sheng Yi Dong، نويسنده , , Chang Xin Zhou، نويسنده , , Li Hong Hu، نويسنده , , Yi-Hang Wu، نويسنده , , Hai Bo Li، نويسنده , , Jing Xu Gong، نويسنده , , Lian Li Sun، نويسنده , , Xiu Mei Wu، نويسنده , , Hua Bai، نويسنده , , Bo Tao Fan، نويسنده , , Xiao Jiang Hao، نويسنده , , Joachim St?ckigt، نويسنده , , Yu Zhao، نويسنده ,
Abstract :
Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed on six human tumor cell lines such as PC-3, CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 μM, which showed more cytotoxic activity than the positive control, cisplatin. The structure–cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template.
Keywords :
Synthesis , CoMFA analysis , Cytotoxicity , Sinapyl alcohol derivatives
