Author/Authors :
Lucie Guetzoyan، نويسنده , , Florence Ramiandrasoa، نويسنده , , Hélène Dorizon، نويسنده , , Christine Desprez، نويسنده , , Alexandre Bridoux، نويسنده , , Christophe Rogier، نويسنده , , Bruno Pradines، نويسنده , , Martine Perrée-Fauvet، نويسنده ,
Abstract :
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 ⩽ 0.20 μM.
Keywords :
Plasmodium falciparum , Peptidic synthesis , antimalarial , aminoacridine
