Title of article
2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols Original Research Article
Author/Authors
Palwinder Singh، نويسنده , , Anu Mittal، نويسنده , , Subodh Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
3990
To page
3996
Abstract
The allylation of appropriate benzoin in presence of indium metal followed by m-CPBA mediated cyclization gave 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols. Investigations on 59 human tumor cell lines of these compounds identify four compounds exhibiting significant growth inhibition of tumor cells at particular cell lines. Compound 12 is very specific toward CCRF-CEM and SR cell lines of leukemia.
Keywords
2 , 3-Diaryltetrahydrofurans , COX-2 , Allylation , Benzoins , 59 Human tumor cell lines , Epoxidation , Anti-cancer agents , Cancer propagation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305818
Link To Document