Studies of interactions between platinum(II) complexes and some biologically relevant molecules Original Research Article

The reactions of Pt(II) complexes, cis-[Pt(NH3)2Cl2], [Pt(terpy)Cl]+, [Pt(terpy)(S-cys)]2+, and [Pt(terpy)(N7-guo)]2+, where terpy = 2,2′:6′,2″-terpyridine, S-cys = l-cysteine, and N7-guo = guanosine, with some biologically relevant ligands such as guanosine-5′-monophosphate (5′-GMP), l-cysteine, glutathione (GSH) and some strong sulfur-containing nucleophiles such as diethyldithiocarbamate (dedtc), thiosulfate (sts), and thiourea (tu), were studied in aqueous 0.1 M Hepes at pH of 7.4 using UV–vis, stopped-flow spectrophotometry, and 1H NMR spectroscopy.