Title of article
New antitumoral acetogenin ‘Guanacone type’ derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone Original Research Article
Author/Authors
Isabel Barrachina، نويسنده , , Inmaculada ROYO، نويسنده , , Héctor A. Baldoni، نويسنده , , Nadia Chahboune، نويسنده , , Fernando Suvire، نويسنده , , Nuria DePedro، نويسنده , , M. Carmen Zafra-polo، نويسنده , , Almudena Bermejo، نويسنده , , Noureddine El Aouad، نويسنده , , Nuria Cabedo، نويسنده , , Jairo Saez، نويسنده , , José R. Tormo، نويسنده , , Ricardo D. Enriz، نويسنده , , Diego Cortes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
13
From page
4369
To page
4381
Abstract
We describe herein the isolation and semisynthesis of four acetogenin derivatives (1–4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.
Keywords
Annonaceae acetogenins , molecular dynamics simulation , Mitochondrial complex I , Tumor cell lines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305853
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