Title of article
C-Terminally PEGylated hGH-derivatives Original Research Article
Author/Authors
Bernd Peschke، نويسنده , , Magali Zundel، نويسنده , , Sonja Bak، نويسنده , , Trine R. Clausen، نويسنده , , Niels Blume، نويسنده , , Anja Pedersen، نويسنده , , Florencio Zaragoza، نويسنده , , Kjeld Madsen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
14
From page
4382
To page
4395
Abstract
A two-step strategy was used for the preparation of C-terminally PEGylated hGH-derivatives. In a first step a CPY-catalyzed transpeptidation was performed on hGH-Leu-Ala, introducing reaction handles, which were used in the second step for the ligation of PEG-moieties. Both oxime-ligation and copper(I) catalyzed [2+3]-cycloaddition reactions were used for the attachment of PEG-moieties. The biological data show a dependency of the potency of the hGH-derivatives on both size as well as shape of the PEG-group.
Keywords
Human growth hormone , PEG , Carboxypeptidase Y , Enzymes , protein , Oxime , 1 , Click-reaction , 2 , hGH , CPY , 3-Triazoles , C-terminus , Ligation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305854
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