Author/Authors :
Jason Xiang، نويسنده , , Manus Ipek، نويسنده , , Vipin Suri، نويسنده , , May Tam، نويسنده , , Yuzhe Xing، نويسنده , , Nelson Huang، نويسنده , , Yanling Zhang، نويسنده , , James Tobin، نويسنده , , Tarek S. Mansour، نويسنده , , John McKew، نويسنده ,
Abstract :
The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors and the mechanism of inhibition are described here. This class of compounds is not active against 11β-HSD2 and therefore may have therapeutic potential for metabolic syndrome and type 2 diabetes.
Keywords :
Synthesis , 11?-HSD1 , Diabetes , HSD1 , Keto sulfone , Metabolic syndrome
