Title of article :
Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid Original Research Article
Author/Authors :
I.S. Marcos، نويسنده , , M.A. Escola، نويسنده , , R.F Moro، نويسنده , , P. Basabe، نويسنده , , D. Diez، نويسنده , , F. Sanz، نويسنده , , F. Mollinedo، نويسنده , , J. de la Iglesia-Vicente، نويسنده , , B.G. Sierra، نويسنده , , J.G Urones، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC50 in the low micromolar range.
Keywords :
Dysidiolide analogues , ent-halimic acid , Sesterterpenolides , Antitumour activity
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
