Title of article
Aza analogues of equol: Novel ligands for estrogen receptor β Original Research Article
Author/Authors
Wuhong Chen، نويسنده , , Zhaohu Lin، نويسنده , , Mengmeng Ning، نويسنده , , Chunhao Yang، نويسنده , , Xueming Yan، نويسنده , , Yuyuan Xie، نويسنده , , Xu Shen، نويسنده , , Mingwei Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
9
From page
5828
To page
5836
Abstract
3-Aryl-tetrahydroquinolines, aza analogues of equol, are synthesized and evaluated for their binding properties to the estrogen receptors ERα and ERβ. Several of these compounds exhibited binding selectivity for ER similar to that of genistein. Compounds 8c and 8d were found to have dual actions: antagonists for ERα and agonists for ERβ in a yeast two-hybrid assay. These compounds have no estrogenic effects on the uterus and bone in vivo.
Keywords
Antioxidant agents , anti-inflammatory agents , Lipoxygenase inhibitors , Aryl-acetic acids
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305972
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