Title of article :
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults Original Research Article
Author/Authors :
Keiko Nishio، نويسنده , , Akiko Fukuhara، نويسنده , , Yo Omata، نويسنده , , Yoshiro Saito، نويسنده , , Shuuhei Yamaguchi، نويسنده , , Hisatoyo Kato، نويسنده , , Yasukazu Yoshida، نويسنده , , Etsuo Niki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
10332
To page :
10337
Abstract :
There is increasing evidence indicating that free radicals and oxygenases such as cyclooxygenase (COX) and lipoxygenase (LOX) are related to the onset and development of neurodegenerative diseases. In order to prevent and/or delay these diseases, the use of radical-scavenging antioxidants and inhibitors against oxygenases has received much attention. In the present study, we examined the radical-scavenging activity and cytoprotective effects of some novel furan compounds with potent inhibitory activity against oxygenases such as COX-1, COX-2, and 5-LOX. The radical-scavenging activity was assessed by studying the bleaching of β-carotene by free radicals generated from an azo initiator. In this assay system, the rate constants for scavenging peroxyl radicals by furan S and furan L was estimated to be 2 × 104 and 3 × 104 M−1 s−1, respectively. We also investigated the cytoprotective effects of these compounds against cell death induced by several toxins. We found that the furan compounds exhibited cytoprotective effects against PC12 cell death induced by linoleic acid hydroperoxide, primary neuronal cell death induced by glutamate, and cell death induced by lipopolysaccharide. These results suggest the beneficial effects of the furan compounds against disorders related to glutamate and lipopolysaccharide.
Keywords :
oxidative stress , Lipopolysaccharide , Glutamate , Cyclooxygenase , Radical scavenging activity , Neuronal cell death , Lipoxygenase
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2008
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1306137
Link To Document :
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