Title of article
Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening
Author/Authors
Hendra Gunosewoyo، نويسنده , , Mark J. Coster، نويسنده , , Maxwell R. Bennett، نويسنده , , Michael Kassiou، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
5
From page
4861
To page
4865
Abstract
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
Keywords
P2X7 antagonists , Cytokine release , rational drug design , LL-37
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306141
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