Title of article
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure–activity relationship of spiroindoline class compounds Original Research Article
Author/Authors
Toshihiro Sakamoto، نويسنده , , Minoru Moriya، نويسنده , , Hiroyasu Tsuge، نويسنده , , Toshiyuki Takahashi، نويسنده , , Yuji Haga، نويسنده , , Katsumasa Nonoshita، نويسنده , , Osamu Okamoto، نويسنده , , Hirobumi Takahashi، نويسنده , , Aya Sakuraba، نويسنده , , Tomoko Hirohashi، نويسنده , , Takunobu Shibata، نويسنده , , Tetsuya Kanno، نويسنده , , Junko Ito، نويسنده , , Hisashi Iwaasa، نويسنده , , Akira Gomori، نويسنده , , Akane Ishi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
12
From page
5015
To page
5026
Abstract
Spiroindoline urea derivatives, designed to act as NPY Y5 receptor antagonists, were synthesized and their structure–activity relationships were investigated. Of these derivatives, compound 3a showed good Y5 binding affinity with favorable pharmacokinetic properties. Compound 3a significantly inhibited bPP Y5 agonist-induced food intake in rats, and suppressed body weight gain in DIO mice.
Keywords
Neuropeptide Y , NPY , Y5 receptor , Spiroindoline , Obesity , Phenyl imidazole
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306161
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