Title of article
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A2A and A3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites Original R
Author/Authors
Lisa Michielan، نويسنده , , Chiara Bolcato، نويسنده , , Stephanie Federico، نويسنده , , Barbara Cacciari، نويسنده , , Magdalena Bacilieri، نويسنده , , Karl-Norbert Klotz، نويسنده , , Sonja Kachler، نويسنده , , Giorgia Pastorin، نويسنده , , Riccardo Cardin، نويسنده , , Alessandro Sperduti، نويسنده , , Giampiero Spalluto، نويسنده , , Stefano Moro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
16
From page
5259
To page
5274
Abstract
G Protein-coupled receptors (GPCRs) selectivity is an important aspect of drug discovery process, and distinguishing between related receptor subtypes is often the key to therapeutic success. Nowadays, very few valuable computational tools are available for the prediction of receptor subtypes selectivity.
Keywords
Adenosine receptors , G protein-coupled receptor , Support vector machine , Selectivity profile , QSAR
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306188
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