Title of article :
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy Original Research Article
Author/Authors :
Pierfausto Seneci، نويسنده , , Aldo Bianchi، نويسنده , , Cristina Battaglia، نويسنده , , Laura Belvisi، نويسنده , , Martino Bolognesi، نويسنده , , Andrea Caprini، نويسنده , , Federica Cossu، نويسنده , , Elena de Franco، نويسنده , , Marilenia de Matteo، نويسنده , , Domenico Delia، نويسنده , , Carmelo Drago، نويسنده , , Amira Khaled، نويسنده , , Daniele Lecis، نويسنده , , Leonardo Manzoni، نويسنده , , Moira Marizzoni، نويسنده , , Elo، نويسنده ,
Abstract :
Novel proapoptotic Smac mimics/IAPs inhibitors have been designed, synthesized and characterized. Computational models and structural studies (crystallography, NMR) have elucidated the SAR of this class of inhibitors, and have permitted further optimization of their properties. In vitro characterization (XIAP BIR3 and linker-BIR2–BIR3 binding, cytotox assays, early ADMET profiling) of the compounds has been performed, identifying one lead for further in vitro and in vivo evaluation.
Keywords :
Smac , XIAP , apoptosis , Oncology , rational drug design , NMR , medicinal chemistry , Crystallography
