Title of article :
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors Original Research Article
Author/Authors :
Takayoshi Suzuki، نويسنده , , Keiko Imai، نويسنده , , Erika Imai، نويسنده , , Shinsuke Iida، نويسنده , , Ryuzo Ueda، نويسنده , , Hiroki Tsumoto، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
A series of 2-anilinobenzamide derivatives were designed, synthesized and evaluated for their SIRT1-inhibitory activity. Among these, compounds 3 and 5 inhibited SIRT1 activity in enzyme assays and suppressed the growth of Daudi and HCT116 cells.
Keywords :
SIRT1 inhibitor , Enzyme assay , Tumor cell growth inhibition , 2-Anilinobenzamide derivative , Daudi cells , HCT116 cells
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
