Title of article
Structural and biological evaluation of some loloatin C analogues Original Research Article
Author/Authors
Adriaan W. Tuin، نويسنده , , Gijsbert M. Grotenbreg، نويسنده , , Emile Spalburg، نويسنده , , Albert J. de Neeling، نويسنده , , Roos H. Mars-Groenendijk، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Daan Noort، نويسنده , , Herman S. Overkleeft، نويسنده , , Mark Overhand، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
8
From page
6233
To page
6240
Abstract
Loloatin C is a cyclic cationic antimicrobial peptide which is active against Gram positive as well as certain Gram negative bacteria. Unfortunately, it is equally potent against human erythrocytes. To probe the structure–activity relationship of this promising antibiotic peptide, amino acid substitution and/or incorporation of a constraint sugar amino acid dipeptide isoster has been applied. Six new derivatives have been synthesized using SPPS and their solution structure investigated using NMR studies. Finally, the antimicrobial and the hemolytic activities have been determined.
Keywords
Loloatin C , Sugar amino acid , Structure–activity relationship , Cationic antimicrobial peptide
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306309
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