Title of article
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists Original Research Article
Author/Authors
Masaki Asada، نويسنده , , Tetsuo Obitsu، نويسنده , , Toshihiko Nagase، نويسنده , , Isamu Sugimoto، نويسنده , , Yoshiyuki Yamaura، نويسنده , , Kazutoyo Sato، نويسنده , , Masami Narita، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
16
From page
6567
To page
6582
Abstract
A series of acrylic acids and their structurally related compounds were evaluated for their binding affinity to four EP receptor subtypes (EP1-4). Starting from the initial hit 3, which was discovered in our in-house library, compounds 4 and 5 were identified as new chemical leads as candidates for further optimization towards a selective EP3 receptor antagonist. The identification process of these compounds and their pharmacokinetic profiles are presented.
Keywords
Prostaglandin , EP3 receptor , Pyrazole , Antagonist
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306350
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