Title of article :
Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-l-aspartic acid as inhibitors of aminopeptidase N/CD13 Original Research Article
Author/Authors :
Yingzi Liu، نويسنده , , Luqing Shang، نويسنده , , Ku-Hao Fang، نويسنده , , and Huawei Zhu، نويسنده , , Jiajia Mu، نويسنده , , Qiang Wang، نويسنده , , Xuejian Wang، نويسنده , , Yumei Yuan، نويسنده , , Wenfang Xu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
A series of novel derivatives of N-cinnamoyl-l-aspartic acid were designed, synthesized, and assayed for their inhibitory activities against aminopeptidase N. The preliminary biological assay showed that compound 8c has the most potent inhibitory activity against APN with an IC50 of 11.1 ± 0.9 μM, this could be used as the lead compound in future research on anticancer agents.
Keywords :
N-Cinnamoyl-l-aspartic acid derivatives , Aminopeptidase N inhibitors , Synthesis
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
