Title of article :
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids Original Research Article
Author/Authors :
Marc Lamblin، نويسنده , , Basel Dabbas، نويسنده , , Russell Spingarn، نويسنده , , Rodrigo Mendoza-Sanchez، نويسنده , , Tiantian Wang، نويسنده , , Beum-Soo An، نويسنده , , Dao Chao Huang، نويسنده , , Richard Kremer، نويسنده , , John H. White، نويسنده , , James L. Gleason، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Incorporation of zinc-binding groups into the side-chain of 1α,25-dihydroxyvitamin D3 (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.
Keywords :
Vitamin D , Vitamin D receptor (VDR) , VDR agonists , HDAC inhibitors , transcriptional regulation , Zinc-binding groups , Hybrid molecules , Dual pharmacophores , Histone deacetylases (HDACs)
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
