Title of article :
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors Original Research Article
Author/Authors :
Hee-Kyung Rhee، نويسنده , , So Yun Lim، نويسنده , , Mi-Ja Jung، نويسنده , , Youngjoo Kwon، نويسنده , , Myung-Hwa Kim، نويسنده , , Hea-Young Park Choo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-1 inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.
Keywords :
PARP-1 , isoquinolinone , Cytotoxic potentiation
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
