Title of article
Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors Original Research Article
Author/Authors
Hee-Kyung Rhee، نويسنده , , So Yun Lim، نويسنده , , Mi-Ja Jung، نويسنده , , Youngjoo Kwon، نويسنده , , Myung-Hwa Kim، نويسنده , , Hea-Young Park Choo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
5
From page
7537
To page
7541
Abstract
The isoquinolinone-based tetracyclic compounds were designed and synthesized and their PARP-1 inhibitory activity was evaluated. Most of synthesized compounds showed fairly good activity. Also the most active compound 6 showed its activity on potentiation of anticancer agents, temozolamide and etoposide, by 1.7 times, respectively.
Keywords
PARP-1 , isoquinolinone , Cytotoxic potentiation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306511
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