Author/Authors :
Yongli Du، نويسنده , , Qunyi Li، نويسنده , , Bing Xiong، نويسنده , , Xin Hui، نويسنده , , Xin Wang، نويسنده , , Yang Feng، نويسنده , , Tao Meng، نويسنده , , Dingyu Hu، نويسنده , , Datong Zhang، نويسنده , , Mingwei Wang، نويسنده , , Jingkang Shen، نويسنده ,
Abstract :
A novel class of non-steroidal progesterone receptor antagonists with aromatic β-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization.
Keywords :
Progesterone receptor (PR) , Progesterone receptor antagonist , Non-steroidal progesterone receptor antagonist , Aromatic ?-amino-ketone , Mannich reaction
