Title of article
Antitumor activity of diethynylfluorene derivatives of gold(I) Original Research Article
Author/Authors
Chung Hin Chui، نويسنده , , Raymond Siu Ming Wong، نويسنده , , University of Perugia Roberto Gambari، نويسنده , , Gregory Yin Ming Cheng، نويسنده , , Marcus Chun-wah Yuen، نويسنده , , Kit-Wah Chan، نويسنده , , See-Wai Tong، نويسنده , , Fung Yi Lau، نويسنده , , Paul Bo San Lai، نويسنده , , Kim-Hung Lam، نويسنده , , Cheuk-Lam Ho، نويسنده , , Chi-Wai Kan، نويسنده , , Kelvin Sze-Yin Leung، نويسنده , , Wai Yeung Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
6
From page
7872
To page
7877
Abstract
A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure–activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
Keywords
alkynes , Gold(I) complexes , Fluorenes derivatives , Human carcinoma cells , Nude mice model , Reactive oxygen species
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2009
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306556
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