Author/Authors :
Alexandra Pérez-Anes، نويسنده , , Cristina Stefaniu، نويسنده , , Christine Moog، نويسنده , , Jean-Pierre Majoral، نويسنده , , Muriel Blanzat، نويسنده , , Cédric-Olivier Turrin، نويسنده , , Anne-Marie Caminade، نويسنده , , Isabelle Rico-Lattes، نويسنده ,
Abstract :
The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers’ outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC50 in a cell-based HIV-infection model but also a high general cytotoxicity.
